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KMID : 0043319960190010001
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Archives of Pharmacal Research
1996 Volume.19 No. 1 p.1 ~ p.5
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Development and Characterization of Membrane for Local Delivery of Cephalexin
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Shin Sang-Chul
Oh In-Joon
Cho Seong-Jin
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Abstract
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Laminated films composed of drug-containing reservoir layer and drug-free membrane were prepared. Zero-order drug release with lag time was achieved by laminating drug-free film onto the reservoir layer, while burst effect was observed on cast-on film. The rate controlling membrane was either attached to or cast directly into the reservoir. The release rate was independent on the reservoir composition but dependent on the composition of rate-controlling membrane. In growth inhibitory test of cephalexin from Eudragit RS film to Streptococcus Mutans, the disk even after release test for 72 hours showed more bacterial growth inhibition than that of control. Permeation of drug through rat skin was proportional to the HPC fraction in the film. We could control the release of cephalexin from the film by changing the fraction of Eudragit RS, HPC and DEP content. Consequently, Eudragit RS/HPC film was found to be very effective system for local delivery of drugs.
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KEYWORD
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Cephalexin, Percutaneous, Transdermal, Local, Delivery, Eudragit, Hydroxy-propylcellulose
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